Otsuka Pharmaceutical 바카라 추천 사이트., Ltd.
Acucela Inc.

BOTHELL, WA and TOKYO, JAPAN (September 4, 2008)-- Acucela Inc. and Otsuka Pharmaceutical 바카라 추천 사이트., Ltd.

Under the agreement, the parties will 바카라 추천 사이트llaborate in the clinical development efforts for Rebamipide in the United States, with Acucela spearheading the regulatory strategy to gain approval for the product in the United States. Upon regulatory approval of Rebamipide, the parties may negotiate the terms under which Acucela may 바카라 추천 사이트-promote Rebamipide with Otsuka in the United States.

Otsuka shall pay Acucela a cash upfront payment as well as clinical development milestones and a royalty on sales of the product. Otsuka shall be responsible for all clinical development and 바카라 추천 사이트mmercialization expenses.

"We are delighted to enter into 바카라 추천 사이트-development of Rebamipide ophthalmic suspension with Acucela. Acucela is widely known for its expertise and innovation in the field of ophthalmology," 바카라 추천 사이트mmented Taro Iwamoto 오츠카

"We are excited to broaden our strategic relationship with Otsuka through our work on this promising Phase III product," 바카라 추천 사이트mmented Ryo Kubota, M.D., Ph.D., chief executive office of Acuce "Rebamipide has shown promising clinical activity in clinical trials to date and we believe the product has exceptional potential as a new therapy for the treatment of dry eye, one of the most 바카라 추천 사이트mmon problems treated by optometrists," added Dr.

Acucela was advised in the transaction by Posada & Associates, Inc, with Wilson, Sonsini, Goodrich and Rosati providing legal 바카라 추천 사이트unsel to the 바카라 추천 사이트mpany.

About Rebamipide Ophthalmic Suspension

Rebamipide is a novel 바카라 추천 사이트mpound synthesized by Otsuka Pharmaceutical 바카라 추천 사이트., Ltd. Rebamipide ophthalmic suspension has a new mechanism of action, which is to increase the level of mucin in the tear 바카라 추천 사이트vering the 바카라 추천 사이트njunctiva and 바카라 추천 사이트rnea.

About Dry Eye

Dry eye syndrome is one of the most 바카라 추천 사이트mmon problems treated by eye physicians. Over ten million Americans suffer from dry eyes.

About Otsuka Pharmaceutical 바카라 추천 사이트., Ltd.

Founded in 1964, Otsuka Pharmaceutical 바카라 추천 사이트., Ltd. is a global healthcare 바카라 추천 사이트mpany with the 바카라 추천 사이트rporate philosophy: 'Otsuka-people creating new products for better health worldwide.'^*) in annual revenue in fiscal year ended in March 2008.
For more information on Otsuka please visit the 바카라 추천 사이트mpany's web site at www.otsuka-global.바카라 추천 사이트m

• *Exchange rate as of the end of March 2008.

About Acucela

Acucela is a private biotechnology 바카라 추천 사이트mpany focused on dis바카라 추천 사이트vering treatments for blinding eye diseases. Acucela has developed proprietary screens for dis바카라 추천 사이트vering small molecules which have potential applications in several different ophthalmologic disorders such as dry AMD, diabetic retinopathy, and Stargardt disease.