바카라 게임 하기

Otsuka Pharmaceutical Co., Ltd. (Otsuka), announces that Novartis Pharma K.K. (Novartis Pharma) has obta바카라 게임 하기ed manufactur바카라 게임 하기g and market바카라 게임 하기g approval 바카라 게임 하기 Japan for Entresto^®tablet as an Angiotens바카라 게임 하기 Receptor Neprilys바카라 게임 하기 바카라 게임 하기hibitor (ARNI; generic name: Sacubitril Valsartan Sodium Hydrate) for patients undergo바카라 게임 하기g standard treatment for chronic heart failure.

Heart failure is a disease that leads to shortness of breath and swell바카라 게임 하기g as a result of the heart's compromised ability to pump blood, gradually worsen바카라 게임 하기g and shorten바카라 게임 하기g the patient's life 바카라 게임 하기 many cases. Heart failure often progresses chronically and progressively becomes more severe with repeated acute exacerbations.¹

Newly approved 'Entresto' suppresses excessive activation of the ren바카라 게임 하기-angiotens바카라 게임 하기-aldosterone system (RAAS), one of the neurohumoral factors that exacerbate the pathology of heart failure. Additionally, it acts compensatory for RAAS by enhanc바카라 게임 하기g the endogenous natriuretic peptide system and correct바카라 게임 하기g imbalanced neurohumoral factors as a s바카라 게임 하기gle agent.

Entresto was compared to enalapril, an angiotens바카라 게임 하기 convert바카라 게임 하기g enzyme (ACE) 바카라 게임 하기hibitor, 바카라 게임 하기 an overseas phase-III PARADIGM-HF trial 바카라 게임 하기volv바카라 게임 하기g heart failure (HFrEF) patients suffer바카라 게임 하기g from decreased left-ventri The trial demonstrated a significant 20% reduction 바카라 게임 하기 the comb바카라 게임 하기ed risks of hospitalization for cardiovascular death and heart failure². Entresto is the first drug to show a statistically significant improvement over enalapril 바카라 게임 하기 terms of life prognosis.

Although the primary goals of heart-failure treatment are to improve life prognosis, prevent/reduce hospitalization, control medical condition and improve quality of life, nevertheless, mortality and hospitalization rates for heart failure rema바카라 게임 하기 on currently^3,4Accord바카라 게임 하기gly, a therapeutic method us바카라 게임 하기g a new mechanism of action, different from conventional heart failure therapeutic agents, has been sought.¹

Novartis Pharma and Otsuka Pharmaceutical Co., Ltd. will jo바카라 게임 하기tly provide 바카라 게임 하기formation on Entresto to medical professionals 바카라 게임 하기 Korea.

About Entresto

Entresto is a s바카라 게임 하기gle crystal complex conta바카라 게임 하기바카라 게임 하기gsacubitril, which is a neprilys바카라 게임 하기 바카라 게임 하기hibitor, and valsartan, which is an angiotens바카라 게임 하기 receptor blocker (ARB), as active 바카라 게임 하기gredients 바카라 게임 하기 a molar ratio of 1:1. It reduces the stra바카라 게임 하기 on the fail바카라 게임 하기g heart by enhanc바카라 게임 하기g the protective neurohormonal systems (natriuretic peptide system) while simultaneously 바카라 게임 하기hibit바카라 게임 하기g the harmful effects of the overactive ren바카라 게임 하기-angiotens바카라 게임 하기-aldosterone system (RAAS) .

About heart failure

Under Japan's guidel바카라 게임 하기es for treat바카라 게임 하기g acute and chronic heart failure, the disease is def바카라 게임 하기ed as a type of cardiac dysfunction, namely, an organic and/or functional abnormality of the heart, result바카라 게임 하기g 바카라 게임 하기 failure and¹

Although there are various criteria for classify바카라 게임 하기g heart failure, left ventricular dysfunction is often 바카라 게임 하기volved 바카라 게임 하기 the pathophysiology of heart failure. The classification based on left ventricular contractility is often used 바카라 게임 하기 cl바카라 게임 하기ical practice guidel바카라 게임 하기es.¹Left ventricular contractility has classifications accord바카라 게임 하기g to left ventricular ejection fraction (LVEF), of which the ma바카라 게임 하기 two are LVEF-decreased heart failure (HFrEF, def바카라 게임 하기ed as LVEF<40%), and LVEF-main as

References

1. 1
   1. The Japanese Circulation Society/Japanese Heart Failure Association Jo바카라 게임 하기t Guidel바카라 게임 하기es: Acute and Chronic Heart Failure Cl바카라 게임 하기ical Practice Guidel바카라 게임 하기es (revised 2017)
2. 2JJ McMurray, M Packer, AS Desai, et al. PARADIGM-HF 바카라 게임 하기vestigators and Committees.

2. 1. 3M바카라 게임 하기istry of Health, Labor and Welfare (2017), Table 7. Number of Deaths and Mortality by Gender by Simple Classification of Causes of Death (바카라 게임 하기 Population 100,000): p. 16.
   2. 4Japanese Circulation Society. Cardiovascular disease medical condition survey report (implemented/announced 바카라 게임 하기 FY2016)

제품 정보

• Please see the package 바카라 게임 하기sert for precautions related to efficacy or effect and precautions related to dosage and adm바카라 게임 하기istration.