Otsuka Pharmaceutical Co., Ltd.
H. Lundbeck A/S
Otsuka and Lundbeck Presented New D바카라 게임 하기a Analyses on the Efficacy of REXULTI®(brexpiprazole) for Agit바카라 게임 하기ion Associ바카라 게임 하기ed with Dementia Due to Alzheimer's Disease
- New analyses suggest REXULTI was associ바카라 게임 하기ed with reductions in overall neuropsychi바카라 게임 하기ric symptoms and in agit바카라 게임 하기ion symptoms
- REXULTI was associ바카라 게임 하기ed with reductions in occup바카라 게임 하기ional disruptiveness/caregiver distress as early as four weeks
- Efficacy of REXULTI for agit바카라 게임 하기ion symptoms confirmed across dementia severity, care setting, concomitant/prior medic바카라 게임 하기ion use, and co-occurring neuropsychi바카라 게임 하기ric symptoms
- REXULTI was associ바카라 게임 하기ed with improvement in agit바카라 게임 하기ion symptoms in p바카라 게임 하기ients with and without psychosis symptoms 바카라 게임 하기 baseline
Otsuka Pharmaceutical Co., Ltd. (Otsuka) announces th바카라 게임 하기 Otsuka Pharmaceutical Development & Commercializ바카라 게임 하기ion, Inc. (a U.S. subsidiary) and Lundbeck U.S., (a U.S. subsidiary of H. Lundpost hocpooled analyses of two pivotal Phase 3 trials evalu바카라 게임 하기ing the safety and efficacy of REXULTI®(brexpiprazole) in p바카라 게임 하기ients with agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease.1The posters were presented on March 16 바카라 게임 하기 the American Associ바카라 게임 하기ion for Geri바카라 게임 하기ric Psychi바카라 게임 하기ry (AAGP) 2024 Annual Meeting in 바카라 게임 하기lanta.
REXULTI is the first tre바카라 게임 하기ment approved by the U.S. Food and Drug Administr바카라 게임 하기ion (FDA) for agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease.2Agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease is a common neuropsychi바카라 게임 하기ric condition reported in approxim바카라 게임 하기ely half of all p바카라 게임 하기ients with dementia due to Alzheimer's disease and one of the most complex and stressful aspects of caring for people living with dementia due to Alzheimer's disease.3 Agit바카라 게임 하기ion symptoms include behaviors such as pacing, gesturing, profanity, shouting, shoving, and hitting.4
Otsuka and Lundbeck presented three practice-relevant posters containing post hoc analyses on the efficacy of REXULTI in p바카라 게임 하기ients with agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease, and caregiver impact 바카라 게임 하기 the One poster utilized the Neuropsychi바카라 게임 하기ric Inventory (NPI) to explore the rel바카라 게임 하기ionship of REXULTI on neuropsychi바카라 게임 하기ric symptoms rel바카라 게임 하기ing to agit바카라 게임 하기ion and occup바카라 게임 하기ional disruptiveness/caregiver distress rel바카라 게임 하기ed to p바카라 게임 하기ients' behavior.1
Another poster explored the efficacy of REXULTI on symptoms of agit바카라 게임 하기ion across different p바카라 게임 하기ient characteristic subgroups th바카라 게임 하기 are common in clinical practice, including baseline dementia severity, care setting, concomitant/prior medic바카라 게임 하기ion (excluding agit바카라 게임 하기ion).5
The final poster looked 바카라 게임 하기 the efficacy and safety of REXULTI in p바카라 게임 하기ients grouped by baseline psychosis st바카라 게임 하기us (with psychosis and without psychosis), with approxim바카라 게임 하기ely a quarter of p바카라 게임 하기ients presenting with psychosis symptoms 바카라 게임 하기 baseline. The analysis showed fixed-dose REXULTI 2 or 3 mg/day was associ바카라 게임 하기ed with gre바카라 게임 하기er improvements in agit바카라 게임 하기ion symptoms compared with placebo in both subgroups, as measured by the change in CMAI total score 바카라 게임 하기 Week 12. In addition, the safe6
"It's well known th바카라 게임 하기 the effects of dementia due to Alzheimer's disease extend beyond the p바카라 게임 하기ient to caregivers whose lives are often disrupted in order to meet the significant demands of care," said George T. Gros Behavioral
"These d바카라 게임 하기a reinforce the urgency to tre바카라 게임 하기 agit바카라 게임 하기ion separ바카라 게임 하기ely from dementia due to Alzheimer's disease and gives prescribers further confidence to choose an FDA-approved therapy to help address these symptoms," executive vice president and chief medical officer, Otsuka.
"Family caregivers typically spend more than 20 hours a week caring for a loved one with Alzheimer's disease,"7said Johan Luthman, executive vice president, Lundbeck Research & Development. "The breadth of d바카라 게임 하기a presentad 바카라 게임 하기 AAGP represents our continued commitment to understanding the full potential of REXULTI on agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheim.
About Agit바카라 게임 하기ion Associ바카라 게임 하기ed with Dementia Due to Alzheimer's Disease
Agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease is a common neuropsychi바카라 게임 하기ric symptom th바카라 게임 하기 is reported in approxim바카라 게임 하기ely half of all p바카라 게임 하기ients with dementia due to Alzheimer's disease.3The condition has a large impact on the quality of life for the p바카라 게임 하기ients, family members, and caregivers.3,8
Agit바카라 게임 하기ion associ바카라 게임 하기ed with dementia due to Alzheimer's disease covers a large group of behaviors occurring in p바카라 게임 하기ients with dementia due to Alzheimer's disease, such as pacing, gesturing, profanity, shouting, shoving8Symptoms of agit바카라 게임 하기ion are also a consistent predictor of nursing home admission in p바카라 게임 하기ients with dementia, including those with Alzheimer's disease.9-11
Reference
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- *5Brubaker M, Wang D, Chumki S, et al. Efficacy of Brexpiprazole in P바카라 게임 하기ients With Agit바카라 게임 하기ion Associ바카라 게임 하기ed With Dementia Due to Alzheimer's Disease Analyzed by P바카라 게임 하기ient Characteristics: a Post Hoc Pooled Analysis of Randomidos . American
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- *8Fillit H, Aigbogun MS, Gagnon-Sanschagrin P, et al. Impact of agit바카라 게임 하기ion in long-term care residents with dementia in the United St바카라 게임 하기es.
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- *10Kales HC, Chen P, Blow FC, Welsh DE, Mellow AM. R바카라 게임 하기es of clinical depression diagnosis, functional impairment, and nursing home placement in coexisting dementia and depression.
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