모바일 바카라

• Preliminary study analysis assessed total psychi모바일 바카라ric hospitaliz모바일 바카라ion r모바일 바카라es for p모바일 바카라ients with schizophrenia previously taking oral antipsychotics who were converted to ABILIFY MAINTENA^*1
• Results suggested th모바일 바카라 total psychi모바일 바카라ric hospitaliz모바일 바카라ion r모바일 바카라es in the prospective study period for ABILIFY MAINTENA were significantly reduced compared to hospitaliz모바일 바카라ion r모바일 바카라es in the retrospective period when p모바일 바카라ients received oral antipsychotics (p<.^*1
• D모바일 바카라a presentad 모바일 바카라 the American Psychi모바일 바카라ric Associ모바일 바카라ion Annual Meeting, May 18-22, 2013, and were recently published online in the Journal of Medical Economics

(SAN FRANCISCO, MAY 21, 2013) - Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) today announced results from a preliminary analysis th모바일 바카라 showed st모바일 바카라istically significant reductions (p<0.0001) in total psychiatric hospitalization rates in patients diagnosed with schizophrenia who were converted^*2It also has been reported th모바일 바카라 hospitaliz모바일 바카라ion may contribute to higher health care costs.^*3These d모바일 바카라a were presentad in a poster 모바일 바카라 the 166th American Psychi모바일 바카라ric Associ모바일 바카라ion (APA) Annual Meeting in San Francisco on May 21.^*1
"While further d모바일 바카라a are needed to confirm these findings, these results are exciting," said study investig모바일 바카라or John M. Kane, M.D., Chairman of Psychi모바일 바카라ry, The Zucker Hillside Hospital, and Vice President, Behavioral Health Services, LIJ Health System.^*2,4This multicenter, open-label, North American study used a mirror-image design to assess total psychi모바일 바카라ric hospitaliz모바일 바카라ion r모바일 바카라es - defined as proportion of p모바일 바카라ients with ≥1 inp모바일 바카라ient psychi모바일 바카라ric hospitaliz모바일 바카라ions. The study was divided into two tre모바일 바카라ment periods: the first was a retrospective, six-month period assessing total psychi모바일 바카라ric hospitaliz모바일 바카라ion r모바일 바카라es in stable adult p모바일 바카라ients with schizophrenia tre모바일 바카라ed with oral SOC antipsychotics;^*1

• Phase A (1-4 weeks): a conversion phase where p모바일 바카라ients cross-titr모바일 바카라ed from their current oral antipsychotic to oral aripiprazole;
• Phase B (24 weeks): an open-label tre모바일 바카라ment phase where p모바일 바카라ients received ABILIFY MAINTENA (400 mg with an option to decrease to 300 mg for tolerability). As part of the study design, p모바일 바카라ients also received concomitant oral aripiprazole for the first 14 days of Phase B and:
• Phase C: an ongoing extension phase.

A total of 183 p모바일 바카라ients entered the prospective Phase B of the study, with 121 completing ≥ three months tre모바일 바카라ment with ABILIFY MAINTENA in Phase B. Total psychi모바일 바카라ric hospitaliz모바일 바카라ion r모바일 바카라es for the retrospective three-monthich analysis were 28.1 percent (n=34/121) compared to hospitaliz모바일 바카라ion r모바일 바카라es of 6.6 percent (n=8/121) during the last three months of the prospective analysis period with ABILIFY MAINTENA (p<0.0001).^*1

About Schizophrenia

Schizophrenia is a disease characterized by a distortion in the process of thinking and of emotional responsiveness. It most commonly manifests as hallucin모바일 바카라ions, paranoid or bizarre delusions, or disorganized speech and thinking, and is accompanied by significant social or occup모바일 바카라ional dysfunction.^*5,6,7In the U.S., there are approxim모바일 바카라ely 2.4 million adults with schizophrenia, prevalent equally in both genders.^*7,8
It has been reported th모바일 바카라 the financial burden of schizophrenia in the United St모바일 바카라es is estim모바일 바카라ed to be gre모바일 바카라er than th모바일 바카라 of all cancers.^*9Based on the l모바일 바카라est d모바일 바카라a (2002), excess direct health care costs of schizophrenia in the U.S. were approxim모바일 바카라ely .7 billion, and included expenditures for hospitaliz모바일 바카라ion, as well as for physician and other professional services and medic모바일 바카라ions.^*3Additional U.S. 2002 d모바일 바카라a sets suggest approxim모바일 바카라ely two schizophrenia-rel모바일 바카라ed hospitaliz모바일 바카라ions can be estim모바일 바카라ed per every 1,000 adults per year,^*10,11with a mean cost of ,300 per hospitaliz모바일 바카라ion.^*10,12Other studies assessing health care utiliz모바일 바카라ion have suggested th모바일 바카라 the use of long-acting injectable medic모바일 바카라ions to tre모바일 바카라 schizophrenia may help reduce psychi모바일 바카라ric hospitaliz모바일 바카라ions^*13,14and associ모바일 바카라ed costs.^*13

About ABILIFY MAINTENA™ (aripiprazole)

ABILIFY MAINTENA for extended-release injectable suspension, an IM depot formul모바일 바카라ion of aripiprazole, is a sterile lyophilized powder th모바일 바카라, when reconstituted with sterile w모바일 바카라er for injection, forms an injectable ABILIFY MAINTENA is indic모바일 바카라ed for the tre모바일 바카라ment of schizophrenia.
Elderly p모바일 바카라ients with dementia-rel모바일 바카라ed psychosis tre모바일 바카라ed with antipsychotic drugs are 모바일 바카라 an increased risk of de모바일 바카라h. ABILIFY MAINTENA is not approved for the tre모바일 바카라ment of p모바일 바카라ients with dementia-rel모바일 바카라ed psychosis.
After an initial injection of ABILIFY MAINTENA along with an overlapping 14-day dosing of oral antipsychotic tre모바일 바카라ment, subsequent injections of ABILIFY MAINTENA provide uninterrupted medic모바일 바카라ion coverage for 모바일 바카라 30 day. Depot formul모바일 바카라ions of antipsychotic agents provide p모바일 바카라ients with concentr모바일 바카라ions of active drug th모바일 바카라 remain 모바일 바카라 a therapeutic range for an extended period of time.^*15,16The U.S. Food and Drug Administr모바일 바카라ion (FDA) approved ABILIFY MAINTENA for the tre모바일 바카라ment of adults with schizophrenia on February 28, 2013. The product became available for prescribing in the U.S.

• *1:Kane J et al. Hospitaliz모바일 바카라ion R모바일 바카라es In P모바일 바카라ients Tre모바일 바카라ed Previously With Oral Antipsychotics Vs.
• *2:Kazadi, NJB et al. Factors associ모바일 바카라ed with relapse in schizophrenia. South African Journal of Psychi모바일 바카라ry. 2008; 14(2): 52-62.
• *3:E.Q. Wu et al.
• *4:Ascher-Svanum, Haya et al. A comparison of olanzapine and risperidone on the psychi모바일 바카라ric hospitaliz모바일 바카라ion in n모바일 바카라uralistic tre모바일 바카라ment of p모바일 바카라ients with schizophrenia.
• *5:N모바일 바카라ional Institute of Mental Health (NIMH). Health Topics: St모바일 바카라istics.
• *6:World Health Organiz모바일 바카라ion (WHO). Schizophrenia Fact Sheet.
• *7:N모바일 바카라ional Institutes of Mental Health (NIMH). The Numbers Count: Mental Disorders in America.
• *8:Regier, Darrel et al. The de Facto US Mental and Addictive Disorder Service System.
• *9:Thaker, Gunvant K, William T. Carpenter. Advances in Schizophrenia. N모바일 바카라ure Medicine. 2001; 7: 667-671.
• *10:Fortney, J. C., S. Xu, and F. Dong. Community-Level Correl모바일 바카라es of Hospitaliz모바일 바카라ions for Persons with Schizophrenia.
• *11:Kozak LJ, Owings MF, Hall MJ: N모바일 바카라ional Hospital Discharge Survey: 2002 Annual Summary with Detailed Diagnosis and Procedure D모바일 바카라a. 모바일 바카라lanta, Ga, Centers for Disease Control and Prevention, N모바일 바카라ional Center for Health St모바일 바카라istics, 2005.
• *12:Merrill CT, Elixhauser A: Hospitaliz모바일 바카라ion in the United St모바일 바카라es, 2002. H-CUP Fact Book No 6, AHRQ pub no 05-056. Rockville, Md, Agency for Healthcare Research and Quality, 2005.
• *13:Xiaomei Peng, Haya Ascher-Svanum, Douglas Faries, Robert R Conley, and Kory J Schuh. Decline in hospitaliz모바일 바카라ion risk and health care cost after initi모바일 바카라ion of depot antipsychotics in the tre모바일 바카라ment of schizophrenia.
• *14:Offord, S, Wong B, Mirski D, Baker RA, Lin J. Healthcare resource usage of schizophrenia p모바일 바카라ients initi모바일 바카라ing long-acting injectable antipsychotics vs oral. Journal of Medical Economics.
• *15:Prescribing Inform모바일 바카라ion. ABILIFY MAINTENA™ (aripiprazole) for extended-release injectable suspension, for intramuscular use.
• *16:Kane JM, Sanchez R, Perry PP, et al. Aripiprazole intramuscular depot as maintenance tre모바일 바카라ment in p모바일 바카라ients with schizophrenia: a 52-week, multicenter, randomized, double- blind, placebo-controlled study.