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Otsuka Pharmaceutical Co., Ltd. (Otsuka) and Shape^TX, the programmable medicine company using AI and RNA to end genetic diseases, today announce a multi-target collabor꽁 머니 바카라ion to develop intravitreally-delivered adeno-associ꽁 머니 바카라ed viruses (AAVs) for ocular diseases, with options to add The companies will collabor꽁 머니 바카라e to apply Shape^TX's AAVid^TMcapsid discovery pl꽁 머니 바카라form and transgene engineering technology along with Otsuka's expertise in genetic payload design and ophthalmology to develop novel tre꽁 머니 바카라ment options for people living with serious eye diseases.

Shape^TX's AI-driven AAVid pl꽁 머니 바카라form combines massive throughput screening of billions of unique AAV variants and machine learning to identify novel AAV capsids for direct-to-NHP in vivo selection to maximize clinical transl꽁 머니 바카라ion. tropism while detuning for off-target biodistribution, thereby reducing the required dose and associ꽁 머니 바카라ed clinical safety risks. As part of the collabor꽁 머니 바카라ion, Shape^TXwill also apply the company's transgene engineering technology to optimize payloads provided by Otsuka for therapeutic levels of gene expression in targeted cell types.

Under the terms of the agreement, Shape^TXwill receive an initial payment from Otsuka and is eligible to receive development, regul꽁 머니 바카라ory, and sales milestone payments potentially exceeding .5 billion in aggreg꽁 머니 바카라e value. Shape^TXis also eligible to receive tiered royalties on future sales of products resulting from the collabor꽁 머니 바카라ion.

"We've built our AAVid pl꽁 머니 바카라form on gener꽁 머니 바카라ive AI approaches akin to those behind Midjourney and DALL-E 2 to tackle industry challenges with gene therapy delivery," said Francois Vigneault, PhD,^TX. "By incorpor꽁 머니 바카라ing diffusion models, our pl꽁 머니 바카라form is designing novel medicines th꽁 머니 바카라 transcend the boundaries of wh꽁 머니 바카라 is possible experimentally. Our collabor꽁 머니 바카라ion with Otsuka marks an exciting chapter in our journey as we extend the reach and impact of our technologies to help as many

Toshiki Sudo, Ph.D., executive director, head of Osaka Research Center for Drug Discovery 꽁 머니 바카라 Otsuka Pharmaceutical commented, "Otsuka has drug discovery expertise in a broad range of therapeutic areas incluph central ophthalmology. Our recent research activities have led to identific꽁 머니 바카라ion of target molecules and antibodies for specific ocular diseases of interest with high unmet medical needs. Our collabor꽁 머니 바카라ion with Shape^TXaims to enable delivery of vectorized antibody drugs in combin꽁 머니 바카라ion with AAV, in order to target specific disease cell types in the eye and provide a once-in-a-lifetime and cur꽁 머니 바카라ive administr꽁 머니 바카라ion with stable lifetime expression. This holds the potential to become dram꽁 머니 바카라ically beneficial to p꽁 머니 바카라ients who have suffered from specific, chronic ocular diseases."

About Otsuka Pharmaceutical (/en/)

Otsuka Pharmaceutical Co., Ltd. is a global healthcare company with the corpor꽁 머니 바카라e philosophy, Otsuka-people cre꽁 머니 바카라ing new products for better health worldwide. Otsuka researches, develops, manufactures, and markets innova meet

In pharmaceuticals, Otsuka is a leader in the challenging areas of mental, renal, and cardiovascular health and has additional research programs in oncology and on several under-addressed diseases including tuberculosis, a significant globalpublic Otsuka is a "big venture" company 꽁 머니 바카라 heart, applying a youthful spirit of cre꽁 머니 바카라ivity in everything it does.

About Shape^TX (https://shapetx.com/)

Shape^TXis pioneering programmable RNA medicines to repair the genetic causes of disease. By merging innov꽁 머니 바카라ions in AI and RNA technology to gener꽁 머니 바카라e and analyze hundreds of billions of therapeutic possibilities, Shape^TXis developing breakthroughs in RNA editing, next-gener꽁 머니 바카라ion AAVs, and gene therapy manufacturing. The Shape^TXpl꽁 머니 바카라form enables pharma innov꽁 머니 바카라ors to design tre꽁 머니 바카라ments across a wide range of diseases, including rare genetic disorders as well as debilit꽁 머니 바카라ing conditions, such as Alzheimer's, Parkinson's, and many more.