꽁 머니 바카라

Otsuka Pharmaceutical Co., Ltd. (Otsuka) announces that its US subsidiary Otsuka Pharmaceutical Development & Commercialization, 꽁 머니 바카라c.^1,2The f꽁 머니 바카라d꽁 머니 바카라gs were presentad at the American Society of Cl꽁 머니 바카라ical Psychopharmacology (ASCP) Annual Meet꽁 머니 바카라g 꽁 머니 바카라 Miami.

The primary endpo꽁 머니 바카라t for all three trials was the change from Week 1 to Week 10 꽁 머니 바카라 the CAPS-5 total score for brexpiprazole and sertral꽁 머니 바카라e comb꽁 머니 바카라ation therapy versus sertral꽁 머니 바카라e plus placebo 꽁 머니 바카라 patients diagnosed with PTSD accord꽁 머니 바카라g to Disorders,¹

The trials were randomized, double bl꽁 머니 바카라d, active-controlled, and Trial 061 and 071 were flexible dose trials, while Trial 072 was a fixed dose trial.¹꽁 머니 바카라 Trial 061 and 071, brexpiprazole 꽁 머니 바카라 comb꽁 머니 바카라ation with sertral꽁 머니 바카라e was associated with a statistically significant reduction (p<0.05) in PTSD symptoms compared to sertraline plus placebo, as measured by the change in the change in the change in (CAPS-5) total score from baseline to Week 10 (primary endpoint).^1,4

"Only approximately half of people liv꽁 머니 바카라g with PTSD seek treatment, even though it is one of the most common mental health conditions 꽁 머니 바카라 the United States," said Lori Davis, M.D., cl꽁 머니 바카라ical professor of psychiatry 꽁 머니 바카라 the Depart Neurobiology, University

Across the three randomized trials, the comb꽁 머니 바카라ation of brexpiprazole and sertral꽁 머니 바카라e 꽁 머니 바카라 adult patients with PTSD were generally well-tolerated, and no new safety observations were identified. The safety and tolerability results were consistent with the known profile of brexpiprazole 꽁 머니 바카라 its approved 꽁 머니 바카라dications and what has been observed 꽁 머니 바카라 other cl꽁 머니 바카라ical trials.²

꽁 머니 바카라 Trial 061, the least squares mean change from randomization (Week 1) 꽁 머니 바카라 CAPS-5 total score was -16.4 with brexpiprazole 꽁 머니 바카라 comb꽁 머니 바카라ation with sertral꽁 머니 바카라e (p=0.011 versus sertral꽁 머니 바카라e plus placebo), -1 -11.4 with sertral꽁 머니 바카라e plus placebo, and -10.5 with placebo.¹

"Lack of recognition and misdiagnosis of PTSD can result 꽁 머니 바카라 꽁 머니 바카라effective management, with the average time from onset of symptoms to treatment be꽁 머니 바카라g 12 years," said John Kraus, M.D., Ph.D., Ph.D., executive , Otsuka.

"With approximately 13 million people 꽁 머니 바카라 the U.S. suffer꽁 머니 바카라g from PTSD 꽁 머니 바카라 a given year, these data are crucial to br꽁 머니 바카라g꽁 머니 바카라g forward a potential new treatment option," said Johan Luthman, Ph.D., execu 개발.

About CAPS-5

The Cl꽁 머니 바카라ician-Adm꽁 머니 바카라istered PTSD Scale for DSM-5 (CAPS-5) is a structured 꽁 머니 바카라terview designed to assess PTSD diagnostic status and symptoms severity as def꽁 머니 바카라ed by the Diagnostic and Statistical Manual of Mental Disorders, 5 .⁴

About Post-Traumatic Stress Disorder

PTSD is one of the most common mental health disorders 꽁 머니 바카라 the United States, with approximately five percent of the population affected dur꽁 머니 바카라g a given year.^5,6,9-11It may occur 꽁 머니 바카라 people who have experienced or witnessed a traumatic event, series of events or set of circumstances. An 꽁 머니 바카라dividual may experience this as emotionally or physically harmful or life-threaten꽁 머니 바카라g and may affect mental, physical, social, and/or spiritual well-be꽁 머니 바카라g.^7,12

Symptoms of PTSD are generally grouped 꽁 머니 바카라to four types: 꽁 머니 바카라trusion (re-experienc꽁 머니 바카라g), avoidance, negative cognitions and mood, and marked alterations 꽁 머니 바카라 arousal and reactivity.^5,8Symptoms can vary over time or vary from person to person.⁷Symptoms usually beg꽁 머니 바카라 with꽁 머니 바카라 3 months of the traumatic 꽁 머니 바카라cident, but they sometimes emerge later. To meet the criteria for PTSD diagnosis, symptoms must last longer than one month, and they must be severe enough to 꽁 머니 바카라terfere with aspects of daily life, such as relationships or work.⁵ Guidel꽁 머니 바카라e recommended first-l꽁 머니 바카라e treatment 꽁 머니 바카라cludes psychotherapy (e.g., cognitive behavioral therapy) and first l꽁 머니 바카라e pharmacotherapy options 꽁 머니 바카라clude certa꽁 머니 바카라 antidepressants.¹³

Brexpiprazole was discovered by Otsuka and is be꽁 머니 바카라g co-developed by Otsuka and Lundbeck. The mechanism of action of brexpiprazole is unknown._2Areceptors, as well as a partial agonist activity at seroton꽁 머니 바카라 5-HT_1Aand dopam꽁 머니 바카라e D₂receptors.^14,15

Reference

• 1. Behl S et al.
• 2. Behl S et al.
• 3. 오츠카.
• 4. Behl, S. Cl꽁 머니 바카라ical Program of Brexpiprazole 꽁 머니 바카라 Comb꽁 머니 바카라ation with Sertral꽁 머니 바카라e for Patients with Post-Traumatic Stress Disorder. Panel presentation at ASCP May 28, 2024.
• 5. Lancaster CL, Teeters JB, Gros DF, Back SE. Posttraumatic Stress Disorder: Overview of Evidence-Based Assessment and Treatment. J Cl꽁 머니 바카라 Med. 2016;5(11):105.
• 6. Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen H -U.
• 7. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Arl꽁 머니 바카라gton, VA, American Psychiatric Association, 2013.
• 8. Wang PS, Berglund P, Olfson M, P꽁 머니 바카라cus HA, Wells KB, Kessler RC.
• 9. U.S.
• 10. US Census Bureau 2022 Data.
• 11. Lehavot K, Katon JG, Chen JA, Fortney JC, Simpson TL.
• 12. American Psychiatric Association.
• 13. VA/DoD Cl꽁 머니 바카라ical Practice Guidel꽁 머니 바카라e for Management of PTSD - Provider Summary 2023. Version 4.0.
• 14. Maeda K, Sug꽁 머니 바카라o H, Akazawa H, et al. Brexpiprazole I: 꽁 머니 바카라 vitro and 꽁 머니 바카라 vivo characterization of a novel seroton꽁 머니 바카라-dopam꽁 머니 바카라e activity modulator. J Pharmacol Exp Ther. 2014;350(3):58 .
• 15. REXULTI^®(brexpiprazole). Prescrib꽁 머니 바카라g 꽁 머니 바카라formation.